GABA:
The Brain's Ability to Neutralize
Stress and Nervous Tension

When brain experiences an abundance of nervous tension and stress, it can be caused by a surplus of norepinephrine or epinephrine (adrenaline). To neutralize this extra adrenaline, the brain produces neurotransmitters, one of which is GABA, that have inhibitory effects upon the nervous system.

The following diagrams explain how the brain uses GABA to calm excessive nervous tension and stress. The diagrams will also show the effect barbiturates, benzodiazepines and alcohol can have on the same brain cells.

Please Note: The two inner rings are receptors for other neurotransmitters that have not yet been scientifically identified. But scientists have discovered that the two inner rings are sensitive to external source substances or chemicals, such as benzodiazepines, barbiturates and alcohol.These external substances attach to the GABA receptor site like neurotransmitters, and can have an effect on the brain similarly to their respective neurotransmittesrs. However, when an external source substance is used to take the place of a natural internal substance for an extended period of time, the body begins to reduce production of those natural chemicals. This can create a deficieny in these naturally occuring chemicals.

L-Glutamine is an amino acid that in a precursor to GABA. Using a nutritional supplement that contains L-Glutamine along with a balanced diet can support the natural replenishment of GABA, as well as other neurotransmitters.

Diagram One: The GABA Receptor Complex

Think of the GABA receptor complex as a round object, like a donut, consisting of three rings, and a center.
  • Center Opening: Chloride Channel
    Chloride neutralizes norepinephrine, thereby calming stress and nervousness. If any two of the rings fill with their respective chemicals, they will cause the 'donut' to tighten, widening the chloride channel to allow more chloride into the brain to neutralize the adrenaline.
  • Outer Ring: GABA Sensitive Ring
    As the brain produces GABA, the molecules attach to the GABA Ring
  • Second Neurotransmitter Ring: Also sensitive to benzodiazepines
    Other neurotransmitters and benzodiazepine molecules attach to the middle ring, which can also assist in opening the chloride channel.
  • Third Neurotransmitter Ring: Also sensitive to barbiturates and alcohol
    Other neurotransmitters, barbiturate and alcohol molecules attach to the inner ring, which can also assist in opening the chloride channel.
See Diagram 2: GABA and the Chloride Channel
See Diagram 3: Benzodiazepines and Barbiturates
Amino Acid Precursors: Science Resources

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IMPORTANT: Nutritional supplements work best in conjunction with a healthy diet. Optimal health does not happen overnight, but requires a building process. Please be faithful to yourself and to your body by taking NGI products on a regular, on-going basis.